De novo design of antibody complementarity determining regions binding a FLAG tetra-peptide

Computational antibody engineering efforts to date have focused on improving binding affinities or biophysical characteristics. De novo design of antibodies binding specific epitopes could greatly accelerate discovery of therapeutics as compared to conventional immunization or synthetic library sele...

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Pubblicato in:Sci Rep
Autori principali: Entzminger, Kevin C., Hyun, Jeong-min, Pantazes, Robert J., Patterson-Orazem, Athena C., Qerqez, Ahlam N., Frye, Zach P., Hughes, Randall A., Ellington, Andrew D., Lieberman, Raquel L., Maranas, Costas D., Maynard, Jennifer A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5579192/
https://ncbi.nlm.nih.gov/pubmed/28860479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10737-9
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