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De novo design of antibody complementarity determining regions binding a FLAG tetra-peptide

Computational antibody engineering efforts to date have focused on improving binding affinities or biophysical characteristics. De novo design of antibodies binding specific epitopes could greatly accelerate discovery of therapeutics as compared to conventional immunization or synthetic library sele...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Entzminger, Kevin C., Hyun, Jeong-min, Pantazes, Robert J., Patterson-Orazem, Athena C., Qerqez, Ahlam N., Frye, Zach P., Hughes, Randall A., Ellington, Andrew D., Lieberman, Raquel L., Maranas, Costas D., Maynard, Jennifer A.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5579192/
https://ncbi.nlm.nih.gov/pubmed/28860479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10737-9
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