Hypoxia induces cancer-associated cAMP/PKA signalling through HIF-mediated transcriptional control of adenylyl cyclases VI and VII

Hypoxia is a phenomenon often arising in solid tumours, linked to aggressive malignancy, bad prognosis and resistance to therapy. Hypoxia-inducible factor-1 has been identified as a key mediator of cell and tissue adaptation to hypoxic conditions through transcriptional activation of many genes invo...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Simko, Veronika, Iuliano, Filippo, Sevcikova, Andrea, Labudova, Martina, Barathova, Monika, Radvak, Peter, Pastorekova, Silvia, Pastorek, Jaromir, Csaderova, Lucia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578998/
https://ncbi.nlm.nih.gov/pubmed/28860539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09549-8
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