A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumor progression

The contribution of lncRNAs to tumor progression and regulatory mechanisms driving their expression are areas of intense investigation. Here, we characterize the binding of heterogeneous nuclear ribonucleoprotein E1 (hnRNP E1) to a nucleic acid structural element located in exon 12 of PNUTS (also kn...

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Pubblicato in:Nat Cell Biol
Autori principali: Grelet, Simon, Link, Laura A., Howley, Breege, Obellianne, Clémence, Palanisamy, Viswanathan, Gangaraju, Vamsi K., Diehl, J. Alan, Howe, Philip H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578890/
https://ncbi.nlm.nih.gov/pubmed/28825698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3595
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