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Hippocampal Perineuronal Nets Are Required for the Sustained Antidepressant Effect of Ketamine

BACKGROUND: N-methyl-D-aspartate receptor antagonists, like ketamine, produce a rapid-acting and long-lasting antidepressant effect. Although the mechanism is not completely understood, ketamine is thought to preferentially target N-methyl-D-aspartate receptors on fast-spiking parvalbumin-containing...

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Detalhes bibliográficos
Publicado no:Int J Neuropsychopharmacol
Main Authors: Donegan, Jennifer J, Lodge, Daniel J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578802/
https://ncbi.nlm.nih.gov/pubmed/27806991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyw095
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