Using DNA methylation profiling to evaluate biological age and longevity interventions

DNA methylation levels of certain CpG sites are thought to reflect the pace of human aging. Here, we developed a robust predictor of mouse biological age based on 90 CpG sites derived from partial blood DNA methylation profiles. The resulting clock correctly determines the age of mouse cohorts, dete...

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Vydáno v:Cell Metab
Hlavní autoři: Petkovich, Daniel A., Podolskiy, Dmitriy I., Lobanov, Alexei V., Lee, Sang-Goo, Miller, Richard A., Gladyshev, Vadim N.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578459/
https://ncbi.nlm.nih.gov/pubmed/28380383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.03.016
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