Using DNA methylation profiling to evaluate biological age and longevity interventions

DNA methylation levels of certain CpG sites are thought to reflect the pace of human aging. Here, we developed a robust predictor of mouse biological age based on 90 CpG sites derived from partial blood DNA methylation profiles. The resulting clock correctly determines the age of mouse cohorts, dete...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Metab
Prif Awduron: Petkovich, Daniel A., Podolskiy, Dmitriy I., Lobanov, Alexei V., Lee, Sang-Goo, Miller, Richard A., Gladyshev, Vadim N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578459/
https://ncbi.nlm.nih.gov/pubmed/28380383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.03.016
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