Retinol saturase coordinates liver metabolism by regulating ChREBP activity

The liver integrates multiple metabolic pathways to warrant systemic energy homeostasis. An excessive lipogenic flux due to chronic dietary stimulation contributes to the development of hepatic steatosis, dyslipidemia and hyperglycemia. Here we show that the oxidoreductase retinol saturase (RetSat)...

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Pubblicato in:Nat Commun
Autori principali: Heidenreich, Steffi, Witte, Nicole, Weber, Pamela, Goehring, Isabel, Tolkachov, Alexander, von Loeffelholz, Christian, Döcke, Stephanie, Bauer, Michael, Stockmann, Martin, Pfeiffer, Andreas F. H., Birkenfeld, Andreas L., Pietzke, Matthias, Kempa, Stefan, Muenzner, Matthias, Schupp, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5577314/
https://ncbi.nlm.nih.gov/pubmed/28855500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00430-w
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