Retinol saturase coordinates liver metabolism by regulating ChREBP activity

The liver integrates multiple metabolic pathways to warrant systemic energy homeostasis. An excessive lipogenic flux due to chronic dietary stimulation contributes to the development of hepatic steatosis, dyslipidemia and hyperglycemia. Here we show that the oxidoreductase retinol saturase (RetSat)...

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Udgivet i:Nat Commun
Main Authors: Heidenreich, Steffi, Witte, Nicole, Weber, Pamela, Goehring, Isabel, Tolkachov, Alexander, von Loeffelholz, Christian, Döcke, Stephanie, Bauer, Michael, Stockmann, Martin, Pfeiffer, Andreas F. H., Birkenfeld, Andreas L., Pietzke, Matthias, Kempa, Stefan, Muenzner, Matthias, Schupp, Michael
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5577314/
https://ncbi.nlm.nih.gov/pubmed/28855500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00430-w
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