α-Synuclein Amyloids Hijack Prion Protein to Gain Cell Entry, Facilitate Cell-to-Cell Spreading and Block Prion Replication

The precise molecular mechanism of how misfolded α-synuclein (α-Syn) accumulates and spreads in synucleinopathies is still unknown. Here, we show the role of the cellular prion protein (PrP(C)) in mediating the uptake and the spread of recombinant α-Syn amyloids. The in vitro data revealed that the...

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Published in:Sci Rep
Main Authors: Aulić, Suzana, Masperone, Lara, Narkiewicz, Joanna, Isopi, Elisa, Bistaffa, Edoardo, Ambrosetti, Elena, Pastore, Beatrice, De Cecco, Elena, Scaini, Denis, Zago, Paola, Moda, Fabio, Tagliavini, Fabrizio, Legname, Giuseppe
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5577263/
https://ncbi.nlm.nih.gov/pubmed/28855681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10236-x
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