Pseudo-acetylation of multiple sites on human Tau proteins alters Tau phosphorylation and microtubule binding, and ameliorates amyloid beta toxicity

Tau is a microtubule-associated protein that is highly soluble and natively unfolded. Its dysfunction is involved in the pathogenesis of several neurodegenerative disorders including Alzheimer’s disease (AD), where it aggregates within neurons. Deciphering the physiological and pathogenic roles of h...

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Publicado no:Sci Rep
Main Authors: Gorsky, Marianna Karina, Burnouf, Sylvie, Sofola-Adesakin, Oyinkan, Dols, Jacqueline, Augustin, Hrvoje, Weigelt, Carina Marianne, Grönke, Sebastian, Partridge, Linda
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5577152/
https://ncbi.nlm.nih.gov/pubmed/28855586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10225-0
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