PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex

PTEN controls three-dimensional (3D) glandular morphogenesis by coupling juxtamembrane signaling to mitotic spindle machinery. While molecular mechanisms remain unclear, PTEN interacts through its C2 membrane-binding domain with the scaffold protein β-Arrestin1. Because β-Arrestin1 binds and suppres...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Javadi, Arman, Deevi, Ravi K, Evergren, Emma, Blondel-Tepaz, Elodie, Baillie, George S, Scott, Mark GH, Campbell, Frederick C
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2017
Assuntos:
Cancer Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576923/
https://ncbi.nlm.nih.gov/pubmed/28749339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.24578
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