Hypermethylation of the non-imprinted maternal MEG3 and paternal MEST alleles is highly variable among normal individuals

Imprinted genes show parent-specific activity (functional haploidy), which makes them particularly vulnerable to epigenetic dysregulation. Here we studied the methylation profiles of oppositely imprinted genes at single DNA molecule resolution by two independent parental allele-specific deep bisulfi...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: Haertle, Larissa, Maierhofer, Anna, Böck, Julia, Lehnen, Harald, Böttcher, Yvonne, Blüher, Matthias, Schorsch, Martin, Potabattula, Ramya, El Hajj, Nady, Appenzeller, Silke, Haaf, Thomas
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2017
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576652/
https://ncbi.nlm.nih.gov/pubmed/28854270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0184030
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