Hypermethylation of the non-imprinted maternal MEG3 and paternal MEST alleles is highly variable among normal individuals

Imprinted genes show parent-specific activity (functional haploidy), which makes them particularly vulnerable to epigenetic dysregulation. Here we studied the methylation profiles of oppositely imprinted genes at single DNA molecule resolution by two independent parental allele-specific deep bisulfi...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Haertle, Larissa, Maierhofer, Anna, Böck, Julia, Lehnen, Harald, Böttcher, Yvonne, Blüher, Matthias, Schorsch, Martin, Potabattula, Ramya, El Hajj, Nady, Appenzeller, Silke, Haaf, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576652/
https://ncbi.nlm.nih.gov/pubmed/28854270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0184030
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