Cryo-EM structure of the SAGA and NuA4 coactivator subunit Tra1 at 3.7 angstrom resolution

Coactivator complexes SAGA and NuA4 stimulate transcription by post-translationally modifying chromatin. Both complexes contain the Tra1 subunit, a highly conserved 3744-residue protein from the Phosphoinositide 3-Kinase-related kinase (PIKK) family and a direct target for multiple sequence-specific...

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Veröffentlicht in:eLife
Hauptverfasser: Díaz-Santín, Luis Miguel, Lukoyanova, Natasha, Aciyan, Emir, Cheung, Alan CM
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2017
Schlagworte:
Structural Biology and Molecular Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576489/
https://ncbi.nlm.nih.gov/pubmed/28767037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.28384
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