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A targeted delivery strategy for the development of potent trypanocides

A new drug delivery strategy was investigated for the development of potent anti-parasitic compounds against Trypanosoma brucei, the causative agent of African sleeping sickness. Thus, potent in vitro hexokinase inhibitors were rendered cytotoxic by appending a tripeptide peroxosomal targeting seque...

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Bibliografski detalji
Izdano u:Chem Commun (Camb)
Glavni autori: Gordhan, Heeren M., Milanes, Jillian E., Qiu, Yijian, Golden, Jennifer E., Christensen, Kenneth A., Morris, James C., Whitehead, Daniel C.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576345/
https://ncbi.nlm.nih.gov/pubmed/28726862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7cc03378h
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