A rectal cancer feasibility study with an embedded phase III trial design assessing magnetic resonance tumour regression grade (mrTRG) as a novel biomarker to stratify management by good and poor response to chemoradiotherapy (TRIGGER): study protocol for a randomised controlled trial

BACKGROUND: Pre-operative chemoradiotherapy (CRT) for MRI-defined, locally advanced rectal cancer is primarily intended to reduce local recurrence rates by downstaging tumours, enabling an improved likelihood of curative resection. However, in a subset of patients complete tumour regression occurs i...

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發表在:Trials
Main Authors: Battersby, Nick J., Dattani, Mit, Rao, Sheela, Cunningham, David, Tait, Diana, Adams, Richard, Moran, Brendan J., Khakoo, Shelize, Tekkis, Paris, Rasheed, Shahnawaz, Mirnezami, Alex, Quirke, Philip, West, Nicholas P., Nagtegaal, Iris, Chong, Irene, Sadanandam, Anguraj, Valeri, Nicola, Thomas, Karen, Frost, Michelle, Brown, Gina
格式: Artigo
語言:Inglês
出版: BioMed Central 2017
主題:
Study Protocol
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576102/
https://ncbi.nlm.nih.gov/pubmed/28851403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-017-2085-2
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