A rectal cancer feasibility study with an embedded phase III trial design assessing magnetic resonance tumour regression grade (mrTRG) as a novel biomarker to stratify management by good and poor response to chemoradiotherapy (TRIGGER): study protocol for a randomised controlled trial

BACKGROUND: Pre-operative chemoradiotherapy (CRT) for MRI-defined, locally advanced rectal cancer is primarily intended to reduce local recurrence rates by downstaging tumours, enabling an improved likelihood of curative resection. However, in a subset of patients complete tumour regression occurs i...

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Veröffentlicht in:Trials
Hauptverfasser: Battersby, Nick J., Dattani, Mit, Rao, Sheela, Cunningham, David, Tait, Diana, Adams, Richard, Moran, Brendan J., Khakoo, Shelize, Tekkis, Paris, Rasheed, Shahnawaz, Mirnezami, Alex, Quirke, Philip, West, Nicholas P., Nagtegaal, Iris, Chong, Irene, Sadanandam, Anguraj, Valeri, Nicola, Thomas, Karen, Frost, Michelle, Brown, Gina
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Study Protocol
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576102/
https://ncbi.nlm.nih.gov/pubmed/28851403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-017-2085-2
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