A Facile Radiolabeling of [(18)F]FDPA via Spirocyclic Iodonium Ylides: Preliminary PET Imaging Studies in Preclinical Models of Neuroinflammation

A suitable TSPO PET ligand may visualize and quantify neuroinflammation in living brain. Herein we report a (18)F-ligand, [(18)F]2 ([(18)F]FDPA) is radiolabeled in high yield and high specific activity based on our spirocyclic iodonium ylide (SCIDY) strategy. [(18)F]2 demonstrated saturable specific...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Wang, Lu, Cheng, Ran, Fujinaga, Masayuki, Yang, Jian, Zhang, Yiding, Hatori, Akiko, Kumata, Katsushi, Yang, Jing, Vasdev, Neil, Du, Yunfei, Ran, Chongzhao, Zhang, Ming-Rong, Liang, Steven H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576052/
https://ncbi.nlm.nih.gov/pubmed/28530834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00432
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