Mechanistic studies and radiofluorination of structurally diverse pharmaceuticals with spirocyclic iodonium(iii) ylides

Synthesis of non-activated electron-rich and sterically hindered (18)F-arenes remains a major challenge due to limitations of existing radiofluorination methodologies. Herein, we report on our mechanistic investigations of spirocyclic iodonium(iii) ylide precursors for arene radiofluorination, inclu...

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Bibliografische gegevens
Gepubliceerd in:Chem Sci
Hoofdauteurs: Rotstein, Benjamin H., Wang, Lu, Liu, Richard Y., Patteson, Jon, Kwan, Eugene E., Vasdev, Neil, Liang, Steven H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Royal Society of Chemistry 2016
Onderwerpen:
Chemistry
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987086/
https://ncbi.nlm.nih.gov/pubmed/27540460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc00197a
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