Discovery of a highly specific 18F-labeled PET ligand for phosphodiesterase 10A enabled by novel spirocyclic iodonium ylide radiofluorination

As a member of cyclic nucleotide phosphodiesterase (PDE) enzyme family, PDE10A is in charge of the degradation of cyclic adenosine (cAMP) and guanosine monophosphates (cGMP). While PDE10A is primarily expressed in the medium spiny neurons of the striatum, it has been implicated in a variety of neuro...

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Main Authors: Zhiwei Xiao, Huiyi Wei, Yi Xu, Ahmed Haider, Junjie Wei, Shiyu Yuan, Jian Rong, Chunyu Zhao, Guocong Li, Weibin Zhang, Huangcan Chen, Yuefeng Li, Lingling Zhang, Jiyun Sun, Shaojuan Zhang, Hai-Bin Luo, Sen Yan, Qijun Cai, Lu Hou, Chao Che, Steven H. Liang, Lu Wang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-04-01
Colecção:Acta Pharmaceutica Sinica B
Assuntos:
Phosphodiesterase 10A
PET radioligand
18F
Spirocyclic iodonium ylide
Nonhuman primate
Target occupancy
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211383521004470
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