Development of Sulfonamide Photoaffinity Inhibitors for Probing Cellular γ-Secretase

γ-Secretase is a multiprotein complex that catalyzes intramembrane proteolysis associated with Alzheimer’s disease and cancer. Here, we have developed potent sulfonamide clickable photoaffinity probes that target γ-secretase in vitro and in cells by incorporating various photoreactive groups and wal...

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Detaylı Bibliyografya
Yayımlandı:ACS Chem Neurosci
Asıl Yazarlar: Crump, Christina J., Murrey, Heather E., Ballard, T. Eric, am Ende, Christopher W., Wu, Xianzhong, Gertsik, Natalya, Johnson, Douglas S., Li, Yue-Ming
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576034/
https://ncbi.nlm.nih.gov/pubmed/27253220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.6b00127
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