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TCR signal strength regulates Akt substrate specificity to induce alternate murine Th and Treg differentiation programs
The Akt/mTOR pathway is a key driver of murine CD4(+) T cell differentiation and induction of T regulatory (Treg) cells results from low TCR signal strength and low Akt/mTOR signaling. However, strong TCR signals induce high Akt activity that promotes T helper (Th) cell induction. Yet, it is unclear...
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| Vydáno v: | J Immunol |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5575766/ https://ncbi.nlm.nih.gov/pubmed/28600288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700369 |
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