Differential regulation of PTEN by TCR, Akt and FoxO1 controls CD4(+) T cell fate decisions()

Signaling via the Akt/mTOR pathway influences CD4(+) T cell differentiation; low levels favor Treg induction and high levels favor Th induction. Although the lipid phosphatase PTEN suppresses Akt activity the control of PTEN activity is poorly studied in T cells. Here, we identify multiple mechanism...

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Bibliographic Details
Published in:J Immunol
Main Authors: Hawse, William F, Sheehan, Robert P., Miskov-Zivanov, Natasa, Menk, Ashley V, Kane, Lawrence P, Faeder, James R, Morel, Penelope A
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4418530/
https://ncbi.nlm.nih.gov/pubmed/25855357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402554
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