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Engineering a Promiscuous Tautomerase into a More Efficient Aldolase for Self‐Condensations of Linear Aliphatic Aldehydes

The enzyme 4‐oxalocrotonate tautomerase (4‐OT) from Pseudomonas putida mt‐2 takes part in a catabolic pathway for aromatic hydrocarbons, where it catalyzes the conversion of 2hydroxyhexa‐2,4‐dienedioate into 2‐oxohexa‐3‐enedioate. This tautomerase can also promiscuously catalyze carbon–carbon bond‐f...

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Bibliografske podrobnosti
izdano v:Chembiochem
Main Authors: Rahimi, Mehran, van der Meer, Jan‐Ytzen, Geertsema, Edzard M., Poelarends, Gerrit J.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575498/
https://ncbi.nlm.nih.gov/pubmed/28426139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201700121
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