Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis

Glutamine-synthetase (GS), the glutamine-synthesizing enzyme from glutamate, controls important events, including the release of inflammatory mediators, mammalian target of rapamycin (mTOR) activation, and autophagy. However, its role in macrophages remains elusive. We report that pharmacologic inhi...

詳細記述

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書誌詳細
出版年:Cell Rep
主要な著者: Palmieri, Erika M., Menga, Alessio, Martín-Pérez, Rosa, Quinto, Annamaria, Riera-Domingo, Carla, De Tullio, Giacoma, Hooper, Douglas C., Lamers, Wouter H., Ghesquière, Bart, McVicar, Daniel W., Guarini, Attilio, Mazzone, Massimiliano, Castegna, Alessandra
フォーマット: Artigo
言語:Inglês
出版事項: Cell Press 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575233/
https://ncbi.nlm.nih.gov/pubmed/28813676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.07.054
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