Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis

Glutamine-synthetase (GS), the glutamine-synthesizing enzyme from glutamate, controls important events, including the release of inflammatory mediators, mammalian target of rapamycin (mTOR) activation, and autophagy. However, its role in macrophages remains elusive. We report that pharmacologic inhi...

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Udgivet i:Cell Rep
Main Authors: Palmieri, Erika M., Menga, Alessio, Martín-Pérez, Rosa, Quinto, Annamaria, Riera-Domingo, Carla, De Tullio, Giacoma, Hooper, Douglas C., Lamers, Wouter H., Ghesquière, Bart, McVicar, Daniel W., Guarini, Attilio, Mazzone, Massimiliano, Castegna, Alessandra
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575233/
https://ncbi.nlm.nih.gov/pubmed/28813676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.07.054
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