Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis

Glutamine-synthetase (GS), the glutamine-synthesizing enzyme from glutamate, controls important events, including the release of inflammatory mediators, mammalian target of rapamycin (mTOR) activation, and autophagy. However, its role in macrophages remains elusive. We report that pharmacologic inhi...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Palmieri, Erika M., Menga, Alessio, Martín-Pérez, Rosa, Quinto, Annamaria, Riera-Domingo, Carla, De Tullio, Giacoma, Hooper, Douglas C., Lamers, Wouter H., Ghesquière, Bart, McVicar, Daniel W., Guarini, Attilio, Mazzone, Massimiliano, Castegna, Alessandra
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575233/
https://ncbi.nlm.nih.gov/pubmed/28813676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.07.054
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados