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Zebrafish model of idiopathic scoliosis link cerebrospinal fluid flow to defects in spine curvature
Idiopathic scoliosis (IS) affects 3% of children worldwide, yet mechanisms underlying spinal deformity remain unknown. Here we show that ptk7 mutant zebrafish, a faithful genetic model of IS, exhibit ependymal cell (EC) cilia development and cerebrospinal fluid (CSF) flow defects. Transgenic re-intr...
Shranjeno v:
| izdano v: | Science |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5574193/ https://ncbi.nlm.nih.gov/pubmed/27284198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf6419 |
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