Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination

The role of the neurovascular niche in CNS myelin regeneration is incompletely understood. Here, we show that, upon demyelination, CNS-resident pericytes (PCs) proliferate, and parenchymal non-vessel-associated PC-like cells (PLCs) rapidly develop. During remyelination, mature oligodendrocytes were...

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Published in:Cell Rep
Main Authors: De La Fuente, Alerie Guzman, Lange, Simona, Silva, Maria Elena, Gonzalez, Ginez A., Tempfer, Herbert, van Wijngaarden, Peter, Zhao, Chao, Di Canio, Ludovica, Trost, Andrea, Bieler, Lara, Zaunmair, Pia, Rotheneichner, Peter, O’Sullivan, Anna, Couillard-Despres, Sebastien, Errea, Oihana, Mäe, Maarja A., Andrae, Johanna, He, Liqun, Keller, Annika, Bátiz, Luis F., Betsholtz, Christer, Aigner, Ludwig, Franklin, Robin J.M., Rivera, Francisco J.
Format: Artigo
Language:Inglês
Published: Cell Press 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5574064/
https://ncbi.nlm.nih.gov/pubmed/28834740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.08.007
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