A Methylidene Group in the Phosphonic Acid Analogue of Phenylalanine Reverses the Enantiopreference of Binding to Phenylalanine Ammonia‐Lyases

Aromatic amino acid ammonia‐lyases and aromatic amino acid 2,3‐aminomutases contain the post‐translationally formed prosthetic 3,5‐dihydro‐4‐methylidene‐5H‐imidazol‐5‐one (MIO) group. MIO enzymes catalyze the stereoselective synthesis of α‐ or β‐amino acid enantiomers, making these chemical processe...

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Dades bibliogràfiques
Publicat a:Adv Synth Catal
Autors principals: Bata, Zsófia, Qian, Renzhe, Roller, Alexander, Horak, Jeannie, Bencze, László Csaba, Paizs, Csaba, Hammerschmidt, Friedrich, Vértessy, Beáta G., Poppe, László
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Full Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573973/
https://ncbi.nlm.nih.gov/pubmed/28919846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adsc.201700428
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