Interplay between recombinant Hsp70 and proteasomes: proteasome activity modulation and ubiquitin-independent cleavage of Hsp70

The heat shock protein 70 (Hsp70, human HSPA1A) plays indispensable roles in cellular stress responses and protein quality control (PQC). In the framework of PQC, it cooperates with the ubiquitin-proteasome system (UPS) to clear damaged and dysfunctional proteins in the cell. Moreover, Hsp70 itself...

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Bibliographic Details
Published in:Cell Stress Chaperones
Main Authors: Morozov, Alexey V., Astakhova, Tatiana M., Garbuz, David G., Krasnov, George S., Bobkova, Natalia V., Zatsepina, Olga G., Karpov, Vadim L., Evgen’ev, Michail B.
Format: Artigo
Language:Inglês
Published: Springer Netherlands 2017
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573687/
https://ncbi.nlm.nih.gov/pubmed/28447215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-017-0792-y
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