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The Hydrophobic Patch of Ubiquitin is Important for its Optimal Activation by Ubiquitin Activating Enzyme E1

Protein ubiquitination plays a role in essentially every process in eukaryotic cells. The attachment of ubiquitin (Ub) or Ub-like (UBL) proteins to target proteins is achieved by parallel but distinct cascades of enzymatic reactions involving three enzymes: E1, E2, and E3. The E1 enzyme functions at...

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Detalhes bibliográficos
Publicado no:Anal Chem
Main Authors: Singh, Rajesh K, Kazansky, Yaniv, Wathieu, Donald, Fushman, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573600/
https://ncbi.nlm.nih.gov/pubmed/28686836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.6b04194
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