A novel fluorometric oligonucleotide assay to measure O( 6)-methylguanine DNA methyltransferase, methylpurine DNA glycosylase, 8-oxoguanine DNA glycosylase and abasic endonuclease activities: DNA repair status in human breast carcinoma cells overexpressing methylpurine DNA glycosylase

DNA repair status plays a major role in mutagenesis, carcinogenesis and resistance to genotoxic agents. Because DNA repair processes involve multiple enzymatic steps, understanding cellular DNA repair status has required several assay procedures. We have developed a novel in vitro assay that allows...

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Autori principali: Kreklau, Emiko L., Limp-Foster, Melissa, Liu, Naili, Xu, Yi, Kelley, Mark R., Erickson, Leonard C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2001
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC55735/
https://ncbi.nlm.nih.gov/pubmed/11410664
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