The Parkinson’s disease-associated GPR37 receptor interacts with striatal adenosine A(2A) receptor controlling its cell surface expression and function in vivo

G protein-coupled receptor 37 (GPR37) is an orphan receptor associated to Parkinson’s disease (PD) neuropathology. Here, we identified GPR37 as an inhibitor of adenosine A(2A) receptor (A(2A)R) cell surface expression and function in vivo. In addition, we showed that GPR37 and A(2A)R do oligomerize...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Morató, Xavier, Luján, Rafael, López-Cano, Marc, Gandía, Jorge, Stagljar, Igor, Watanabe, Masahiko, Cunha, Rodrigo A., Fernández-Dueñas, Víctor, Ciruela, Francisco
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573386/
https://ncbi.nlm.nih.gov/pubmed/28842709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10147-x
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