The Parkinson’s disease-associated GPR37 receptor interacts with striatal adenosine A(2A) receptor controlling its cell surface expression and function in vivo

G protein-coupled receptor 37 (GPR37) is an orphan receptor associated to Parkinson’s disease (PD) neuropathology. Here, we identified GPR37 as an inhibitor of adenosine A(2A) receptor (A(2A)R) cell surface expression and function in vivo. In addition, we showed that GPR37 and A(2A)R do oligomerize...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Morató, Xavier, Luján, Rafael, López-Cano, Marc, Gandía, Jorge, Stagljar, Igor, Watanabe, Masahiko, Cunha, Rodrigo A., Fernández-Dueñas, Víctor, Ciruela, Francisco
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573386/
https://ncbi.nlm.nih.gov/pubmed/28842709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10147-x
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