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The Parkinson’s disease-associated GPR37 receptor interacts with striatal adenosine A(2A) receptor controlling its cell surface expression and function in vivo

G protein-coupled receptor 37 (GPR37) is an orphan receptor associated to Parkinson’s disease (PD) neuropathology. Here, we identified GPR37 as an inhibitor of adenosine A(2A) receptor (A(2A)R) cell surface expression and function in vivo. In addition, we showed that GPR37 and A(2A)R do oligomerize...

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Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Morató, Xavier, Luján, Rafael, López-Cano, Marc, Gandía, Jorge, Stagljar, Igor, Watanabe, Masahiko, Cunha, Rodrigo A., Fernández-Dueñas, Víctor, Ciruela, Francisco
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573386/
https://ncbi.nlm.nih.gov/pubmed/28842709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10147-x
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