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Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer
Proteolysis targeting chimeric molecules (Protacs) target proteins for destruction by exploiting the ubiquitin-dependent proteolytic system of eukaryotic cells.We designed two Protacs that contain the peptide ‘degron’ from hypoxia-inducible factor-1α, which binds to the Von –Hippel–Lindau (VHL) E3 u...
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| Pubblicato in: | Oncogene |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5573236/ https://ncbi.nlm.nih.gov/pubmed/18794799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.320 |
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