The extreme C-terminal region of kindlin-2 is critical to its regulation of integrin activation

Kindlin-2 (K2), a 4.1R-ezrin-radixin-moesin (FERM) domain adaptor protein, mediates numerous cellular responses, including integrin activation. The C-terminal 15-amino acid sequence of K2 is remarkably conserved across species but is absent in canonical FERM proteins, including talin. In CHO cells e...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Hirbawi, Jamila, Bialkowska, Katarzyna, Bledzka, Kamila M., Liu, Jianmin, Fukuda, Koichi, Qin, Jun, Plow, Edward F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572925/
https://ncbi.nlm.nih.gov/pubmed/28652408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.776195
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