Isolation and structure–function characterization of a signaling-active rhodopsin–G protein complex

The visual photo-transduction cascade is a prototypical G protein–coupled receptor (GPCR) signaling system, in which light-activated rhodopsin (Rho*) is the GPCR catalyzing the exchange of GDP for GTP on the heterotrimeric G protein transducin (G(T)). This results in the dissociation of G(T) into it...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Gao, Yang, Westfield, Gerwin, Erickson, Jon W., Cerione, Richard A., Skiniotis, Georgios, Ramachandran, Sekar
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572916/
https://ncbi.nlm.nih.gov/pubmed/28655769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.797100
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