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Interaction between the PH and START domains of ceramide transfer protein competes with phosphatidylinositol 4-phosphate binding by the PH domain

De novo synthesis of the sphingolipid sphingomyelin requires non-vesicular transport of ceramide from the endoplasmic reticulum to the Golgi by the multidomain protein ceramide transfer protein (CERT). CERT's N-terminal pleckstrin homology (PH) domain targets it to the Golgi by binding to phosp...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Prashek, Jennifer, Bouyain, Samuel, Fu, Mingui, Li, Yong, Berkes, Dusan, Yao, Xiaolan
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572904/
https://ncbi.nlm.nih.gov/pubmed/28652409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.780007
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