Phosphoinositide binding by the PH domain in ceramide transfer protein (CERT) is inhibited by hyperphosphorylation of an adjacent serine-repeat motif

Sphingolipids such as ceramide are important constituents of cell membranes. The ceramide transfer protein (CERT) moves ceramide from the endoplasmic reticulum to the Golgi apparatus in a nonvesicular manner. Hyperphosphorylation of the serine-repeat motif (SRM) adjacent to the pleckstrin homology (...

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Udgivet i:J Biol Chem
Main Authors: Sugiki, Toshihiko, Egawa, Daichi, Kumagai, Keigo, Kojima, Chojiro, Fujiwara, Toshimichi, Takeuchi, Koh, Shimada, Ichio, Hanada, Kentaro, Takahashi, Hideo
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Lipids
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052210/
https://ncbi.nlm.nih.gov/pubmed/29848549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002465
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