Decreased Ceramide Transport Protein (CERT) Function Alters Sphingomyelin Production following UVB Irradiation

Increased cellular ceramide accounts in part for UVB irradiation-induced apoptosis in cultured human keratinocytes with concurrent increased glucosylceramide but not sphingomyelin generation in these cells. Given that conversion of ceramide to non-apoptotic metabolites such as sphingomyelin and gluc...

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Main Authors: Charruyer, Alexandra, Bell, Sean M., Kawano, Miyuki, Douangpanya, Sounthala, Yen, Ten-Yang, Macher, Bruce A., Kumagai, Keigo, Hanada, Kentaro, Holleran, Walter M., Uchida, Yoshikazu
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423244/
https://ncbi.nlm.nih.gov/pubmed/18411267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800799200
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