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Hypoalbuminemia Is Significantly Associated with Increased Clearance Time of High Dose Methotrexate in Patients Being Treated for Lymphoma or Leukemia
As a weak acid, methotrexate (MTX) is bound to serum albumin and has variable protein binding. The purpose of this study was to assess serum albumin’s relationship with MTX pharmacokinetics by comparing MTX clearance and toxicities between patients with normal serum albumin to those with hypoalbumin...
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| Publicado no: | Ann Hematol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5572815/ https://ncbi.nlm.nih.gov/pubmed/27542957 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00277-016-2795-7 |
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