SF3B1-initiating mutations in MDS-RSs target lymphomyeloid hematopoietic stem cells

Mutations in the RNA splicing gene SF3B1 are found in >80% of patients with myelodysplastic syndrome with ring sideroblasts (MDS-RS). We investigated the origin of SF3B1 mutations within the bone marrow hematopoietic stem and progenitor cell compartments in patients with MDS-RS. Screening for rec...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Mortera-Blanco, Teresa, Dimitriou, Marios, Woll, Petter S., Karimi, Mohsen, Elvarsdottir, Edda, Conte, Simona, Tobiasson, Magnus, Jansson, Monika, Douagi, Iyadh, Moarii, Matahi, Saft, Leonie, Papaemmanuil, Elli, Jacobsen, Sten Eirik W., Hellström-Lindberg, Eva
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2017
Soggetti:
Hematopoiesis and Stem Cells
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572789/
https://ncbi.nlm.nih.gov/pubmed/28634182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-03-776070
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