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Adhesion to stromal cells mediates imatinib resistance in chronic myeloid leukemia through ERK and BMP signaling pathways

Chronic myeloid leukemia (CML) is characterized by abnormal proliferation of myeloid cells which when untreated leads to bone marrow failure. Imatinib mesylate (IM) is the first line of therapy for treatment of CML and results in remission in most cases. However, a significant percentage of patients...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Kumar, Atul, Bhattacharyya, Jina, Jaganathan, Bithiah Grace
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572702/
https://ncbi.nlm.nih.gov/pubmed/28842696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10373-3
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