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Adhesion to stromal cells mediates imatinib resistance in chronic myeloid leukemia through ERK and BMP signaling pathways

Chronic myeloid leukemia (CML) is characterized by abnormal proliferation of myeloid cells which when untreated leads to bone marrow failure. Imatinib mesylate (IM) is the first line of therapy for treatment of CML and results in remission in most cases. However, a significant percentage of patients...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kumar, Atul, Bhattacharyya, Jina, Jaganathan, Bithiah Grace
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572702/
https://ncbi.nlm.nih.gov/pubmed/28842696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10373-3
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