A novel perspective on stem cell homing and mobilization – review on bioactive lipids as potent chemoattractants and cationic peptides as underappreciated modulators of responsiveness to SDF-1 gradients

Hematopoietic stem/progenitor cells (HSPCs) respond robustly to α-chemokine stromal derived factor-1 (SDF-1) gradients and blockage of CXCR4, a seven-transmembrane-spanning G(αI) protein-coupled SDF-1 receptor, mobilizes HSPCs into peripheral blood (PB). While the SDF-1–CXCR4 axis plays an unquestio...

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Publicado en:Leukemia
Autores principales: Ratajczak, Mariusz Z., Kim, Chi Hwa, Abdel-Latif, Ahmed, Schneider, Gabriela, Kucia, Magda, Morris, Andrew J., Laughlin, Mary J., Ratajczak, Janina
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572626/
https://ncbi.nlm.nih.gov/pubmed/21886175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.242
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