BONE MARROW EXPRESSED ANTIMICROBIAL CATIONIC PEPTIDE LL-37 ENHANCES RESPONSIVENESS OF HEMATOPOIETIC STEM PROGENITOR CELLS TO AN SDF-1 GRADIENT AND ACCELERATES THEIR ENGRAFTMENT AFTER TRANSPLANTATION

We report that the bone marrow stroma-released LL-37, a member of the cathelicidin family of antimicrobial peptides, primes/increases responsiveness of murine and human hematopoietic stem/progenitor cells (HSPCs) to an α-chemokine stromal-derived factor-1 (SDF-1) gradient. Accordingly, LL-37 is upre...

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Detalhes bibliográficos
Main Authors: Wu, Wan, Kim, Chi Hwa, Liu, Rui, Kucia, Magda, Greco, Nicholas, Ratajczak, Janina, Laughlin, Mary L., Ratajczak, Mariusz Z.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3244577/
https://ncbi.nlm.nih.gov/pubmed/21931324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.252
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