Sphingosine-1-phosphate-Mediated Mobilization of Hematopoietic Stem/Progenitor Cells during Intravascular Hemolysis Requires Attenuation of SDF-1-CXCR4 Retention Signaling in Bone Marrow

Sphingosine-1-phosphate (S1P) is a crucial chemotactic factor in peripheral blood (PB) involved in the mobilization process and egress of hematopoietic stem/progenitor cells (HSPCs) from bone marrow (BM). Since S1P is present at high levels in erythrocytes, one might assume that, by increasing the p...

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Bibliographic Details
Main Authors: Mierzejewska, Kasia, Klyachkin, Yuri M., Ratajczak, Janina, Abdel-Latif, Ahmed, Kucia, Magda, Ratajczak, Mariusz Z.
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3891619/
https://ncbi.nlm.nih.gov/pubmed/24490172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/814549
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