Natural IgM and TLR Agonists Switch Murine Splenic Pan-B to “Regulatory” Cells That Suppress Ischemia-Induced Innate Inflammation via Regulating NKT-1 Cells

Natural IgM anti-leukocyte autoantibodies (IgM-ALAs) inhibit inflammation by several mechanisms. Here, we show that pan-B cells and bone marrow-derived dendritic cells (BMDCs) are switched to regulatory cells when pretreated ex vivo with IgM. B cells are also switched to regulatory cells when pretre...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Lobo, Peter I., Schlegel, Kailo H., Bajwa, Amandeep, Huang, Liping, Okusa, Mark D.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572342/
https://ncbi.nlm.nih.gov/pubmed/28878768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00974
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